Two cancer drugs show promise in reversing Alzheimer’s devastating effects

Researchers found letrozone and irinotecan reduced tau protein clumps and improved memory in mice

By Melissa Rudy Fox News

Two cancer drugs could potentially slow or even reverse the effects of Alzheimer’s disease, a new study suggests.

Researchers at the University of California San Francisco (UCSF) explored how the common dementia changes gene expression (which genes are turned on or off) in certain brain cells, according to a press release from the university.

Next, they looked at which existing FDA-approved drugs might counteract, or reverse, those changes.

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In analyzing millions of electronic medical records of adults over 65, the researchers identified two medications that appeared to reduce the likelihood of Alzheimer’s in the patients who took them.

The medications — letrozone and irinotecan — are both approved to treat cancer. Letrozole is a breast cancer medication and irinotecan treats colon and lung cancer.

When the scientists tested a combination of both medications in mice, they noted a reversal of the gene expression changes that were initiated by Alzheimer’s.

Please read more at the below link:

https://www.foxnews.com/health/two-cancer-drugs-show-promise-reversing-alzheimers-devastating-effects

Diem ‘Richard’ Nguyen
Liên Minh Bảo Hiến Mỹ Gốc Việt
Vietnamese American Conservative Alliance (VACA)
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